Oxidative DNA damage arises when reactive oxygen species generated by mitochondrial respiration, inflammatory processes or environmental stressors attack nucleobases and the sugar–phosphate backbone.

This summer, over 50 researchers in the NSF EMBRIO Institute convened to share their newest findings on cellular signaling and organization that drives wound repair, cellular defense, and organismal ...

Researchers from Tel Aviv University have discovered a new biological mechanism that enhances the production of myelin—a substance essential for proper brain function and nerve communication. "Our ...

The dynamic regulation of chromatin accessibility is one of the prominent characteristics of eukaryotic genome. The inaccessible regions are mainly located in heterochromatin, which is multilevel ...

Geroscience shifts the medical focus from treating individual diseases to targeting the fundamental biological drivers of aging. Cellular senescence involves aging cells that cease division but ...

Three biochemical steps of the non-homologous DNA end-joining (NHEJ) process. This figure outlines the key stages of the NHEJ repair mechanism following DNA double-strand breaks. The process can be ...

However, the mechanisms behind this superior biological effectiveness remain unclear. Published in Physical Review X on March 11, a new study has uncovered a key mechanism involving intermolecular ...

As recently as the mid-20th century, aging was described by Nobel Prize laureate Peter Medawar as "an unsolved problem in ...

However, the mechanism through which it does this was previously unknown. A research team led by Prof. Dr. Thomas Laux, a member of the CIBSS—Center for Integrative Biological Signaling Studies ...

Regenerative dentistry has rapidly evolved from traditional repair approaches toward biologically driven strategies that aim to restore the structure and ...

A graphic prepared by Wroclaw Medical University highlighting selected facts discussed in a review article by Dr. Piotr Chmielewski published in Biogerontology. The article examines current theories ...