Researchers at Baylor College of Medicine have developed a powerful new data analysis method named COOKIE-Pro (Covalent ...
In a recent paper in ACS Central Science, researchers report a strategy for targeting covalent modifications to specific sites on proteins. The modifier molecules use an antibody to target a protein ...
New study reveals how mass spectrometry can be used to determine the mechanisms used by molecular glues to stick to their targets. Molecular glues are a continually expanding area of medicinal ...
Misbehaving proteins are behind many diseases. One way drugmakers incapacitate these bad actors is to deploy molecules that bind to them. But finding solid footholds on the proteins to block their ...
Human proteins undergo a variety of chemical modifications following their synthesis. These modifications regulate their structure, function, and stability. Researchers from the Bhogaraju Group at ...
Reversible modification of mitochondrial ADP/ATP translocases by paired Legionella effector proteins
Proceedings of the National Academy of Sciences of the United States of America, Vol. 119, No. 23 (June 7, 2022), pp. 1-11 (11 pages) Adenosine diphosphate (ADP) ribosylation is a reversible ...
Lactylation, a recently identified post-translational modification, has emerged as important for immune regulation, tissue repair, cancer cell metabolism, and now, potentially, Alzheimer’s disease. In ...
Artificial proteins as specific and versatile neutralizing binders targeting the spike of SARS-CoV-2
In a recent article posted to the bioRxiv* preprint server, researchers demonstrated that the biosynthetic proteins called αReps addressing the severe acute respiratory syndrome coronavirus 2 ...
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