Intriguingly, although the DNA-binding domain of Hand2 largely determines its sequence specificity and ability to regulate target gene expression, mutations in Hand2 that abolish DNA-binding ability, ...

Researchers from the MRC Protein Phosphorylation and Ubiquitylation Unit at the University of Dundee, together with collaborators from ETH Zürich, the Malopolska Center of Biotechnology and the ...

WYL-domain containing transcription factors regulate fundamental processes in bacterial physiology, yet how these proteins sense cellular cues to elicit an allosteric response is not well understood.

A discrete helix in the fusion oncoprotein DNA binding domain shifts binding preferences toward long and dense GGAA repeats, which promotes transcriptional hub formation and drives ...

A pA-Tn5 probe (multicoloured) binds an antibody (white), which binds a transcription factor binding domain (green) on DNA (blue) within 2 nucleosomes. The binding of proteins to DNA is crucial for ...