The ability to grow stem cell-derived biological tissues, such as skin and other organs, in the laboratory holds promise for applications in areas including wound healing and transplants. However, ...

Ligand binding affinities at G-protein coupled receptors (GPCRs) have historically been determined using a radioligand that competes for receptor binding sites against an unlabeled drug-like compound.

Clonal hematopoiesis of indeterminate potential (CHIP) is a known risk factor for coronary artery disease, though its precise role in disease progression continues to emerge. This study leverages ...

Humans have about 400 odorant receptors (ORs), but scientists have had trouble finding ligands that match up with most of these ORs in lab settings—leaving them with a murky understanding of how ...

A study from St. Jude Children's Research Hospital uncovered an alternative binding pocket within nuclear receptors, ...

The NEURL E3 ubiquitin ligases selectively activate the Notch ligands DLL1 and JAG1, but not DLL4 and JAG2. This differential ...

The investigational drug BMS-986365 may help patients with mCRPC previously treated with ARPIs overcome drug resistance, despite their genomic status. The investigational dual androgen receptor ...

(1) Synthesis of Notch receptor in endoplasmic reticulum. (2) Notch receptor undergoing S1 cleavage by furine-like convertase in the Golgi apparatus. (3) The transfer of Notch receptor to the cell ...

Data presented at Kidney Week 2025 showed single subcutaneous administration of megalin-STRIKERs resulted in increased excretion of disease-related solute levels lasting for at least 2 months Dr. Ravi ...

Research led by the University of Washington reports on an AI-guided method that designs epitope-specific antibodies and ...