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Advances in the molecular diagnostic methods for circular RNA

Circular RNA (circRNA) is a unique type of non-coding RNA produced by back splicing of mRNA to form the covalent junction without 3’-5’ polarity and poly(A) tail. CircRNA was first discovered about 30 ...
Nature

Self-splicing RNA circularization facilitated by intact group I and II introns

Circular RNA (circRNA) has gained significant attention in RNA therapeutics due to its enhanced stability and protein-coding potential. In this study, we present two in vitro RNA circularization ...
Nature

Circular RNA circLIMK1-005 promotes the progression of lung adenocarcinoma by interacting with RPA1 protein to activate CDK4 signaling

Lung adenocarcinoma (LUAD) is the leading cause of cancer death worldwide. Circular RNAs (circRNAs) have emerged as potential key players in the onset and progression of various cancers. However, the ...
Phys.org

Clearing circular RNA from cells extends lifespan, C. elegans study reveals

Cells in our bodies produce RNA based on genetic information stored in DNA, and RNA serves as a blueprint for making proteins. Researchers at KAIST have discovered a new phenomenon: Removing "circular ...
Phys.org

Introducing HORNET, a novel RNA structure visualization method that correlates sequence and 3D topology

National Cancer Institute researchers have developed a method called HORNET for characterizing 3D topological structures of large and flexible RNA molecules. Scientists used atomic force microscopy ...