News Medical

Study challenges a long-standing idea about the role of Hippo signaling in organ growth

The Hippo signaling pathway – a genetic program thought to play a central role in organ development – does not instruct normal organ growth in flies and mice, according to a new study. The findings, ...
CNN

High-speed hippos can get airborne, says new study

Hippos can get airborne when moving at high speeds over land, according to a new study. This is the first time that the animals, which can weigh more than 2,000 kilograms (2.2 tons) and spend much of ...
GEN

Hippo Signaling Found Not to Be the Long-Considered Master Regulator of Normal Organ Growth

The Hippo signaling pathway, a genetic program thought to play a central role in organ development, does not lead to normal organ growth in flies and mice, according to a new study “Hippo signaling ...
ascopubs.org

A phase 1, first-in-human study of IK-930, an oral TEAD inhibitor targeting the Hippo pathway in subjects with advanced solid tumors.

Design and rationale of a phase 1 dose-escalation study of AMG 193, a methylthioadenosine (MTA)-cooperative PRMT5 inhibitor, in patients with advanced methylthioadenosine phosphorylase (MTAP)-null ...
BioWorld

Study finds Hippo pathway aberrantly activated in NPH1 models, unveiling Kibra as a potential target

Nephronophthisis (NPH) is a recessive cystic kidney disease responsible for 10% to 20% of pediatric end-stage renal disease cases. NPHP1 (nephrocystin 1) is the most frequently implicated among over ...