A second winter storm in as many days is slamming parts of the Midwest before rolling toward the East Coast. Major travel disruptions are likely.

A winter storm headed for Vermont on Saturday and Sunday could drop as much as 10 inches of snow across the state, during one of the biggest weekends of the year for ski areas.

Syracuse, N.Y. -- Even as a lake effect snowstorm is closing highways today in Upstate New York, another storm system is barreling toward the region this weekend. The weekend “will feature very active winter weather as a large, powerful storm system passes through the region,” the National Weather Service said.