The 49ers better be prepared for this challenging unit on the Titans.

The San Francisco 49ers made a significant decision on wide receiver Brandon Aiyuk that could spell the end of his tenure in the Bay Area.

The San Francisco 49ers have placed receiver Brandon Aiyuk on the reserve/left squad list, making him ineligible to return from a knee injury this season.

The San Francisco 49ers‘ defense has been ravaged by injuries, most notably to Fred Warner and Nick Bosa. Nonetheless, defensive coordinator Robert Saleh is working with what he has available and putting out a respectable group that has the Niners in a playoff spot heading into Week 15.

Sunday’s game at Levi’s Stadium could get out of hand quickly. The San Francisco 49ers will host the Tennessee Titans as 12.5-point favorites in Week 15. The un

So if the Niners let him play out his contract, shake his hand, and watch him sign a solid $20-to-$30 (maybe $40) million-dollar deal elsewhere in free agency come the end of the 2026 season, the league office will essentially FedEx a third-round pick (fourth at worst) to Santa Clara. That’s money in the bank. That’s a free lottery ticket.