Researchers at Baylor College of Medicine have developed a powerful new data analysis method named COOKIE-Pro (Covalent ...

In a recent paper in ACS Central Science, researchers report a strategy for targeting covalent modifications to specific sites on proteins. The modifier molecules use an antibody to target a protein ...

New study reveals how mass spectrometry can be used to determine the mechanisms used by molecular glues to stick to their targets. Molecular glues are a continually expanding area of medicinal ...

Misbehaving proteins are behind many diseases. One way drugmakers incapacitate these bad actors is to deploy molecules that bind to them. But finding solid footholds on the proteins to block their ...

Covant Therapeutics, Roivant’s latest spin-off company, will have a major partner with whom to explore the benefits of covalency, courtesy of an exclusive research pact and licensing deal with ...

Lactylation, a recently identified post-translational modification, has emerged as important for immune regulation, tissue repair, cancer cell metabolism, and now, potentially, Alzheimer’s disease. In ...

Researchers at Baylor College of Medicine have developed an artificial intelligence (AI) model that reveals how protein modifications link genetic mutations to disease. The method, called DeepMVP and ...

One of the first things that students learn when they enter a biology class is the central dogma: DNA → messenger RNA → proteins. Only about 3% of the human genome directly codes for proteins, which ...

In a recent article posted to the bioRxiv* preprint server, researchers demonstrated that the biosynthetic proteins called αReps addressing the severe acute respiratory syndrome coronavirus 2 ...