In early life, the innate immune system can recognize both viable and nonviable parts of microorganisms. Immune activation may direct the immune response, thus conferring tolerance to allergens such ...

Endotoxin removal from a finished product is a major challenge for biopharmaceutical manufacturers; particularly as all endotoxin removal methods have operational limitations and may result in loss of ...

Inadequate endotoxin testing places patients at risk. Knowing the relative strengths and weaknesses of available test methods is crucial to maintaining quality and safety. Endotoxins are small, ...

In pharmaceutical research and development as well as basic scientific research, recombinant proteins serve not only as essential research tools but also as potential therapeutic agents or key factors ...

Surf on a beach at sunset features a horseshoe crab upside down in the water and several others nearby. Regulatory changes may make the pharmaceutical industry less reliant on horseshoe crabs for ...

ACROBiosystem's SAFENSURE ™ Recombinant Factor C Endotoxin Detection Kit is a novel endotoxin detection kit powered by recombinant Factor C technology. Comparable to LAL method - The endpoint ...

Endotoxin refers to a component of the outer cell membrane of Gram-negative bacteria called lipopolysaccharide (LPS). LPS is the biologically active portion of naturally occurring endotoxin complexes.

CHICAGO -- Blood purification using polymyxin B showed a mortality reduction signal in patients with septic shock and high endotoxin activity, researchers reported here. In the phase III Tigris trial, ...

Escherichia coli is widely considered the most cost-effective bacterial system for recombinant protein expression. Consequently, it is broadly used. Nonetheless, it has its limitations as an ...