In early life, the innate immune system can recognize both viable and nonviable parts of microorganisms. Immune activation may direct the immune response, thus conferring tolerance to allergens such ...

Endotoxin removal from a finished product is a major challenge for biopharmaceutical manufacturers; particularly as all endotoxin removal methods have operational limitations and may result in loss of ...

In pharmaceutical research and development as well as basic scientific research, recombinant proteins serve not only as essential research tools but also as potential therapeutic agents or key factors ...

Understanding the relative strengths and weaknesses of different endotoxin test methods is crucial to maintaining quality and patient safety. Endotoxins are small, hydrophobic molecules that are part ...

Surf on a beach at sunset features a horseshoe crab upside down in the water and several others nearby. Regulatory changes may make the pharmaceutical industry less reliant on horseshoe crabs for ...

Endotoxin refers to a component of the outer cell membrane of Gram-negative bacteria called lipopolysaccharide (LPS). LPS is the biologically active portion of naturally occurring endotoxin complexes.

CHICAGO -- Blood purification using polymyxin B showed a mortality reduction signal in patients with septic shock and high endotoxin activity, researchers reported here. In the phase III Tigris trial, ...

ACROBiosystem's SAFENSURE ™ Recombinant Factor C Endotoxin Detection Kit is a novel endotoxin detection kit powered by recombinant Factor C technology. Comparable to LAL method - The endpoint ...

The presence of harmful bacteria in parenteral drugs or implantable devices can cause inflammatory responses such as fever and, in some cases, may even be fatal. As a result, robust bacterial ...