Cancer cells' stress shield cracked by compound that binds in one place, inhibits in another

Cancer cells are pretty bold and clever—they hijack cellular survival and healing processes in order to fuel their growth, ...
IEEE

Predicting Single-Cell Drug Sensitivity Utilizing Adaptive Weighted Features for Multi-Source Domain Adaptation

Abstract: The advancement of single-cell sequencing technology has promoted the generation of a large amount of single-cell transcriptional profiles, providing unprecedented opportunities to identify ...
ahajournals.org

Single‐Cell Transcriptome Profiling Reveals Dynamic Cell Populations and Immune Infiltration in Moyamoya Disease

The cellular composition and molecular mechanisms of the pathological arteries in Moyamoya disease (MMD) remain poorly understood. To improve our understanding of pathogenesis in MMD, we aimed to ...
GitHub

Modeling and predicting single-cell multi-gene perturbation responses with scLAMBDA

We present scLAMBDA, a deep generative learning framework designed to model and predict single-cell transcriptional responses to genetic perturbations, including single-gene and combinatorial ...
GEN

Single-Cell Proteomics Reveal Hidden Layers of Gene Expression

Single cell gene expression studies often rely on single-cell RNA sequencing (scRNA-seq) alone. While scRNA-seq reveals which genes are turned on, it does not capture protein expression or changes to ...
gut.bmj

Single-cell multimodal analysis reveals the dynamic immunopathogenesis of HBV-ACLF progression

3 Transplantation Center, The Third Xiangya Hospital, Central South University, Changsha, China Background Acute-on-chronic liver failure (ACLF) is a life-threatening syndrome involving dysfunction of ...